Local contact correction reduced motion prediction error in 27 cells from one mouse retina
We tested how local contact opportunity changes a structure-based prediction of motion direction in one mouse retina. We used 27 matched On-Off direction-selective ganglion cells from e2198 and kept the published angle conversion. Correction reduced mean error from 52.7 degrees to 14.7 degrees. The paired reduction was 37.9 degrees, with a descriptive 95% cell bootstrap interval of 21.9 to 55.9 degrees. A mean from other cells of the same type had error 12.8 degrees. Shuffles within each type did not give clear added evidence for the individual cell match: p = 0.063 for the primary trace estimate and p = 0.936 for published response fits. The correction benefit stayed positive after every single-cell removal. The within-type result changed with cell removal and response estimation. These results quantify the benefit of an existing contact correction and limit a claim of cell-specific precision. The sample comes from one retina, and the supplied types use contact direction in part. Contacts are not all synapses. The package contains new analysis code, derived tables, figures, source hashes, fixed source versions, and reproduction instructions.
retina · structure and function · starburst amacrine cells · motion direction · contact opportunity · type-preserving permutation · e2198
References
2- usesdoi:10.1038/nature09818
We use the matched calcium and anatomical measurements from the e2198 retina. The source established the link between starburst input direction and ganglion cell motion preference.
- usesdoi:10.1016/j.cell.2018.04.040
We use its public cell groups, cell matches, contact opportunity counts, and response fits. We quantify its correction method and add a type-preserving cell-matching test.
Cited by
9 publicationsPublic catalog entries on Sciscape.
- In one mouse retina, bipolar kinetics read through dendrite depth predicted response transience of On ganglion cells (Spearman 0.58; polarity only −0.12), not of Off cells or within types
Same e2198 data set, starburst contact correction for direction prediction.
- In one mouse retina, image position reduced motion vector test error in a short trailing edge window but not a broad window
This work tests contact opportunity correction and compares response definitions in the same retina.
- usesWith cell type given, contact concentration raised error by 13% in a fixed linear test of motion selectivity strength in 27 On-Off cells from one mouse retina
We use its description of the matched panel and source conventions. Our independent scalar extraction reproduces its contact concentration and fitted response strength values. We test strength rather than angle.
- usesA linear inhibitory rule for starburst contacts gave no clear added axis tuning prediction in 269 ganglion cells from one mouse retina
We use its record of the published angle transform and opportunity correction. We test a different angular order.
- In one mouse retina, dendrite depth predicted the polarity and part of the time course of 47 held-out ganglion cell types; bipolar-type overlap and bipolar kinetics added little
Same e2198 data; structure-based prediction of direction preference.
- usesSeparate ON and OFF contact directions gave no clear added direction match within type in 27 cells from one mouse retina
We retain its source cohort and sector conventions, and test a distinct within-cell layer-pairing contrast.
- With independent repeat errors, starburst contact features captured 1.25% of residual motion-vector energy in 302 cells from one mouse retina
This prior study tested local contact correction in the same cells.
- In a fixed test of 5,542 pairs from one mouse retina, dendrite depth overlap gave an uncertain 0.21% error decrease for residual calcium correlation
Prior SCI anatomy-to-motion test and source-format discussion in the same resource.
- supportsWith surface opportunity fixed, removal of 1.16–17.35% of contact counts moved predicted direction by 45 degrees in 27 mouse retinal cells
Prior comparison showed the practical effect of surface-opportunity correction in these cells. Our test keeps that correction fixed.