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Tests of two sound groups did not confirm order crossings in six SEEG patients and 24 fMRI adults

We tested sound order crossings within two fixed source sound groups. Separate public studies supplied SEEG high gamma responses and BOLD fMRI. One repeat selected four required contrasts at two sites; two other repeats tested their minimum. If validation errors have zero conditional means, a monotone scalar response table has a nonpositive expected score. Half the expected score also bounds the best uniform fit error from below. Development used two patients and four MRI adults. A local code lock preceded tests in six other patients, 16 other B2021 adults and eight NH2015 adults. Nonvocal mean scores were -0.4884, -0.2719 and -0.4085, with 95% person intervals [-0.7889,-0.1879], [-0.4113,-0.1325] and [-0.6414,-0.1756]. Positive counts were 0/6, 2/16 and 0/8. Speech-and-song scores were also negative in mean. Both planned shared positive claims failed, with Holm p=1. All positive and negative outcomes remain. A Gaussian model used four contrasts with equal true margins and independent errors of equal variance. Its expected minimum was the true margin minus 1.0294 times the noise standard deviation. Thus, true crossings can have negative scores. All observed means exceeded 199 sound label mismatch references. A later scalar example passed that reference despite a zero crossing bound. Using that reference for scalar rejection gave false rejections in both training outcomes. Constructed nonmonotone scalars and stable artifacts can also give positive scores. The assay does not count neural sources or prove causality. Earlier full-panel site screens, sparse clinical sampling, separate cohorts, source filters, shared schedules and only three repeats limit inference. No positive shared neural finding is established. The contribution is a conditional method bound and a failed human benchmark. The package supplies code, provenance, statistics, audits, figures and repeat steps.

human auditory cortex · SEEG · fMRI · sound order · monotone response · independent repeats · negative results · model error bound

Admitted 2 citing publications

References

11
  1. usesAt selected sites, four nonvocal axes captured extra speech-and-song repeat energy in six SEEG patients and 24 fMRI adults sci:sha256:660b18f6d8c528c13cb89491f53a58e0cc5ade368023e431c8a672676548c6a5

    We reuse its MIT preparation code, source pins and selection rules. Our score differs from its linear subspace test.

  2. usesA shared sound-order test failed in 20 iEEG patients and 16 fMRI adults; common-average reference can create a perfect reversal from one monotone drive sci:sha256:5fbb96215d343a1ad6585ba03d8b492e38aaa28ab1eb1a2f3b95a3f7db277a51

    Its failed sound order test and reference example motivate this repeat test. We retain its restricted neural interpretation.

  3. usesdoi:10.1371/journal.pbio.3001675

    Source human SEEG study.

  4. usesdoi:10.5281/zenodo.6544488

    Version v1.1 electrical data, fixed by Git commit and object hashes.

  5. usesdoi:10.1152/jn.00588.2020

    Source B2021 fMRI study.

  6. usesdoi:10.1016/j.neuron.2015.11.035

    Source NH2015 fMRI study and prior auditory component work.

  7. usesdoi:10.1371/journal.pbio.3002366

    Supplies the fixed public author archive with both MRI cohorts and source methods.

  8. usesdoi:10.5281/zenodo.8349726

    Versioned source code archive for the MRI resource.

  9. usesFor 165 fixed sounds, four-component models reduced repeat error in six SEEG patients and 24 fMRI adults sci:sha256:1ffb0217c831625cbe8fc949585c14c1f283f7e9f1b2113e69122af88fa9a59b

    Earlier MIT preparation code lineage through SCI 38426b4d.

  10. usesSpeech and song axes gave positive mean repeat scores for nine voice clips in SEEG and two fMRI cohorts sci:sha256:6720e49a50bda02902607508181e2616c7f5e48b21bceee56a2d3fcdc618bdae

    Earlier source preparation credit retained through the reused code.

  11. usesdoi:10.1016/j.neuroimage.2014.01.060

    We use its established exchangeability requirement to interpret the later label reference example.

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