Equal averages of nearby spines gave no clear extra agreement between orientation signals from the two eyes in 11 mice
We tested whether input position supports agreement between visual signals from the two eyes after linear pooling. We used separate eye calcium recordings from selected dendritic spines in mouse visual cortex. Equal averages of 5,142 nearby pairs and 6,306 distant pairs gave mismatch estimates of 87.27% and 87.30%. The nearby minus distant difference was -0.03 percentage points, with a 95% whole-mouse bootstrap interval from -4.43 to +6.65 points. The sample had 3,568 participating spine records, 222 fields, 13 neurons and 11 mice. The measure includes both eye amplitude and orientation agreement. Separate repeat products reduce independent trial noise under fixed processed units. Planned processing and matched-pair checks gave intervals that included zero. A planned secondary same-spine check found 7.85 points more agreement than the within-field identity expectation, with interval 2.46 to 13.47 points. A later mean-of-mouse-ratios check also gave no clear local benefit. The main result limits this equal linear average and broad selected sample. It does not establish an absence of local synaptic organization. Shared image processing, separate eye scans, finite trial counts and unknown synaptic gains limit the biological inference. The package preserves compact input data, source hashes, code, all results and draws, figures, a local plan and offline repeat instructions.
dendritic spines · binocular vision · visual cortex · linear pooling · orientation tuning · structure and function · calcium imaging · repeat noise
References
9- usesdoi:10.5281/zenodo.19372968
The version 1.0 dataset supplies spine positions and separate eye calcium recordings. Compact arrays are preserved with source attribution.
- usesdoi:10.1016/j.isci.2026.115861
The source paper defines the experiment and source processing and reports local visual tuning organization.
- usesIn 11 mice, spine pairs in visual cortex gave no clear extra eye-response agreement at 2–5 versus 10–20 µm after total-response control sci:sha256:2178e5f5a66d4fc55fbe899e7a826acb91fb6f78faeecc42aeb35582053087cb
We reuse its verified compact monocular arrays, fractional scale recovery, provenance, and MIT source extraction tools.
- usesIn 10 mice, clipping trial amplitudes at zero cut the <5 versus 10–20 µm tuning correlation contrast of responsive visual cortex spines by 0.085 in tests with odd and even repeats sci:sha256:fe21349f81db26fc0fed7410847f79826d047b45849490025a94aafa867af7e2
Its checked signed-amplitude reconstruction is inherited through the monocular extract. We retain the original attribution.
- In 19 mice, sums of two spine calcium signals gave no clear local advantage in a linear orientation test sci:sha256:da4e0418b4c7a5421d3ed0be32428f9c29e32f04fcb1051c035b6b320f74ef87
This prior study tests linear orientation readout from spine pairs under binocular stimulation. Our test concerns agreement between separate eye signals after an equal average.
- In 11 mice, patterns of shared calcium variation between spines repeated across eye conditions after linear controls sci:sha256:48ac126847f9c974b55f4b5e387059c622f2f544af3beb620a8cfb53236410a0
This prior study tests shared trial variation across eye conditions. It gives related context for signal stability.
- doi:10.1016/j.neuron.2022.01.023
This study links binocular synaptic input signals to interocular alignment in ferret visual cortex.
- doi:10.1038/s41467-025-60825-y
This study links spine turnover and visual response organization during binocular circuit development in mice.
- doi:10.7554/eLife.46966
This study separates tuning and shared trial variation in dendritic signals. Separate trial estimates motivate the noise control.
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