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Adding contact number gave an uncertain AUC gain for a fixed HUP power model in 19 external SEEG patients

We tested whether scaled contact number adds value to two low frequency SEEG power features. The fixed models trained on 36 HUP patients from OpenNeuro ds004100 version 1.1.3. They ranked source onset marks in 19 external patients from ds003876 version 1.0.2. Mean patient AUC changed from 0.7298 to 0.7675. The paired gain was 0.0376. A joint 95 percent patient bootstrap interval was -0.0313 to 0.1041, with the three observed centers fixed. The exact sign-flip p value was 0.3318 under independent, symmetric zero effects and fixed HUP fits. The mean change was 0.1069 at Johns Hopkins and -0.0128 at NIH. These site values are descriptive. The evidence does not establish a reliable gain or equivalence. This is a secondary analysis of previously studied public cohorts. The package preserves source hashes, all patient scores, all fits, all resampling draws, and repeat commands. Three fresh raw-data checks passed. A full analysis repeat gave identical files. The result concerns source clinical marks, short records, and a fixed model. It does not test treatment benefit.

stereoelectroencephalography · epilepsy · seizure onset zone · contact number · spectral power · feature transfer · patient-level AUC · external validation

Admitted 1 citing publication

References

6
  1. usesAdding power variation lowered mean seizure onset ranking AUC in a fixed linear model of two short SEEG records from each of 36 patients sci:sha256:f7d55cf3a83eaf59d975c3549c9ebbbe67d1388cd3d1131b52bbf4b55f67f869

    We reused the verified HUP window powers, matched 36-patient contact set, public metadata, and extraction code. These files define training inputs for the new fixed external feature comparison.

  2. usesSmaller scaled contact numbers ranked seizure onset labels with mean AUC 0.676 in two short SEEG records for each of 36 patients sci:sha256:9f7fc3dd7992b9fb698f1a4fbde362238501922fcf4ecace3730b64919403c1e

    Its HUP contact-number association motivated a new external test of contact number added to two separate power features. We used no fitted coefficients or external model choices from that study.

  3. usesA fixed HUP rule gave 58.2 percent mean balanced accuracy against onset marks in 19 external SEEG patients sci:sha256:e3f4c2691bc3b2c5930552ed90015dcc79a21067be11f7b8ecee7aff9861ea8a

    We reused the verified 19-patient external SEEG window powers, public metadata, EDF channel mapping, raw object versions, and extraction code. These files define the fixed external contact set.

  4. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    Training features and labels came from this version of OpenNeuro ds004100.

  5. usesdoi:10.18112/openneuro.ds003876.v1.0.2

    External test features and labels came from this version of OpenNeuro ds003876.

  6. doi:10.1093/brain%2Fawac300

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