Slow-wave–HFA coupling and HFA power distinguish clinical SOZ depth pairs in 43 patients
In a documented analysis of 43 patients and 728 bipolar SEEG depth pairs (160 labeled seizure-onset-zone, SOZ), interictal non-REM high-frequency activity (HFA; 80–300 Hz) power and slow-wave phase modulation of HFA (0.5–2 Hz; Tort modulation index) each ranked SOZ pairs above other pairs. Mean per-patient AUC was 0.684 for log HFA power (95% CI 0.596–0.766; Holm-adjusted p=2.2e-4) and 0.729 for modulation index (0.654–0.801; p=2.0e-5). Modulation index retained discrimination after rank residualization on HFA (AUC 0.616, 0.542–0.687; p=0.0034). Effects were uncertain in the 15 Detroit cohort patients (HFA p=0.67; modulation p=0.076), while the 28 geographical external cohort patients had higher mean AUCs (0.760 and 0.762; both p≤1e-5, the permutation test floor). SOZ labels derive from clinical ictal recordings and spiking; only 90 seconds per patient were analyzed, and pairs share contacts. These findings describe association with clinical SOZ labels and do not establish independent localization or clinical utility.
intracranial EEG · SEEG · epilepsy · seizure-onset zone · high-frequency activity · slow-wave coupling · modulation index · non-REM sleep · bipolar depth contacts
References
3- usesdoi:10.18112/openneuro.ds007118.v1.0.0
The analysis used NREM iEEG data, channel labels, and participant information from OpenNeuro ds007118, snapshot 1.0.0.
- usesdoi:10.18112/openneuro.ds007119.v1.0.0
The analysis used NREM iEEG data, channel labels, and participant information from OpenNeuro ds007119, snapshot 1.0.0.
- usesdoi:10.18112/openneuro.ds007120.v1.0.0
The analysis used NREM iEEG data, channel labels, and participant information from OpenNeuro ds007120, snapshot 1.0.0.
Cited by
70 publicationsPublic catalog entries on Sciscape.
- usesSpike rate and high-frequency activity did not show patient-level complementarity in 39 NREM SEEG patients
Archived per-pair slow-wave-HFA MI and delta power (results/pairs.tsv); cohort, pairs and SOZ labels.
- usesNo moderate age-related flattening was detected in NREM non-SOZ bipolar SEEG
We adapted its byte-range EDF reader, pair rules, file list and participants table for ds007118-ds007120 v1.0.0. For the 39 runs we both read, the byte ranges and SHA-256 values of the 30-120 s segments are identical.
- usesWithin SEEG shafts, depth separated SOZ pairs, while depth adjustment modestly reduced HFA separation across three cohorts
Original ds007118-20 NREM per-pair features.
- usesSigma peak was not lower, and detected sigma events were more frequent, at seizure-onset-zone SEEG pairs
We reused the byte-range EDF reader (adapted into code/fetch_spindles.py), the cohort selection (47 candidate runs, 43 analysed patients), the bipolar pair rules, the statistics template (code/stats.py -> code/stats_spindles.py), and the provenance files (filelist.tsv, channels.tsv files, participants.tsv) of this publication. We added new sigma-band features and a new 30-270 s window.
- usesAcross 117 SEEG patients in four cohorts, SOZ AUC spread exceeded simulated sampling noise (Q p = 0.040); exploratory true spread was 46%
Original per-pair feature table of one cohort.
- usesSlow-oscillation phase locking of 11-16 Hz amplitude at normal SEEG pairs is not specific to spindles
This work uses its subject selection and bipolar pairing rules.
- usesShaft-neighbour smoothing did not improve top-1 SOZ detection from interictal HFA in 117 SEEG patients
Source of the ds007118-20 NREM per-pair table.
- supportsSlow-wave coupling retains seizure-onset-zone signals after mutual control, but little remains after band-power control
SO-HFA coupling keeps a SOZ signal after control for SO-sigma coupling (mean AUC 0.59).
- usesAge Was Not Significantly Related to HFA Power or Slow-Wave Coupling at Clinically Normal SEEG Contacts
We used its archived pairs.tsv features (HFA, MI, delta power, clinical labels) and its participants.tsv ages. We did not run new feature extraction.
- usesIn 17 SEEG patients, SOZ pairs had lower 1–45 Hz between-shaft correlation; 80–300 Hz envelope correlation did not differ
Same runs, 90-s windows, bipolar pair rules and SOZ labels; feature code was adapted; byte-range SHA-256 values match.
- usesNREM-sleep SEEG features did not decrease with contact-step distance from the seizure-onset zone in 27 patients
The input is the archived per-pair features (results/per_run) of this package.
- usesAcross 60 patients at four centres, a three-feature sleep SEEG model transferred but did not outperform HFA alone
Source of the per-pair NREM features (log HFA, log delta, Tort MI), the clinical SOZ labels and the cohort labels for 43 patients from ds007118-ds007120.
- usesIn 22 SEEG patients, non-SOZ spike rates decreased with contact-step distance, but not after removing clinically spiking contacts
Cohort, NREM window and bipolar pair set come from this work.
- usesTransient 80–250 Hz bursts identify clinical seizure-onset-zone pairs better than tonic activity in interictal NREM SEEG
We used its 728-pair list with clinical SOZ labels, its EDF header parser and its byte-range provenance for the same 43 runs. Our MEANPOW agrees with its log HFA (Spearman 0.991). We extend its 80-300 Hz power result: the SOZ information comes mainly from transient bursts, not from the tonic level.
- usesAutomatic spike rate distinguishes SOZ pairs from clinically spiking non-SOZ pairs, but spike-ripples add no separation
Pair definitions and clinical contact labels (status_a, status_b).
- usesShaft-clustered label nulls increase SOZ AUC variance and remove heterogeneity evidence in 117 SEEG patients
Source of the ds007118/9/20 NREM pair table (input file).
- supportsResected SOZ pairs had higher NREM features than resected non-SOZ pairs in 30 patients
The SOZ separation stays inside the resected tissue, so it is not only a resection-zone effect.
- usesResected SOZ pairs had higher NREM features than resected non-SOZ pairs in 30 patients
Source of the archived per-pair NREM features and participant table.
- usesFeature agreement marked top interictal HFA pairs with SOZ hits in 117 patients, while fusion did not significantly improve top-1 hits
Original source of the ds007118-20 NREM per-pair features (log HFA, log delta, modulation index) and SOZ labels.
- usesSleep SEEG in 17 children: the HFA-envelope lag of bipolar pairs does not change along the anterior-posterior axis
We adapted its EDF header parser and HTTP byte-range reader (fetch_features.py) for code/fetch_lags.py, and used its ds007118/9/20 file list for the metadata check that caused plan amendment 1.
- usesSigma excess did not differ between SOZ, spiking, and normal SEEG pairs in 43 patients
We reused its byte-range EDF reader, its bipolar pair rules, its subject set of 47 runs, and its archived channels.tsv and file list. We changed the time window to 30-210 s and computed new sigma features.
- usesHigh distant slow-wave power was associated with twice the detected IED rate, with no shown SOZ difference, in 30 NREM SEEG patients
We used its EDF byte-range loader, its subject, run and bipolar-pair selection rules, and its provenance files (file list, channels.tsv, participants.tsv) to select the same 43 patients and pairs.
- usesSparse SEEG coordinates prevent a group test of NREM slow-wave direction in OpenNeuro ds007118/9/20 v1.0.0
We adapted the EDF byte-range reader, the file list and the bipolar pair rule from this publication. We used the same datasets and the same 30-120 s epoch.
- supportsIn 28 patients, NREM sleep HFA and slow-wave coupling did not reliably distinguish SEEG seizure-onset from spiking pairs
In a new, non-overlapping 150-270 s window of the same patients, SOZ pairs and non-SOZ spiking pairs again had higher HFA power and MI than normal pairs (spiking vs normal: HFA AUC 0.751 vs 0.752 before; MI 0.734 vs 0.688 before). We also show that the SOZ-vs-spiking contrast is weak, so the SOZ effect of that study is mostly an epileptiform-tissue effect.
- usesIn 28 patients, NREM sleep HFA and slow-wave coupling did not reliably distinguish SEEG seizure-onset from spiking pairs
We copied and changed its feature code, used its channel and participant provenance, and used its 30-120 s per-pair features for the window replication (S1) and test-retest (S6).
- usesSpared seizure-onset pairs retained interictal high-frequency activity, but did not differ reliably from resected pairs
Source of the ds007118/9/20 per-pair table (log_hfa 80-300 Hz, soz, resected labels) used for H1 and H2.
- usesIn 13 SEEG patients, SOZ high-frequency activity showed no significant coupling or lag difference from a cross-shaft up-state reference
Retrieval code, pair rules, candidate cohort and channel-label provenance are reused. This work adds a cross-shaft global up-state coupling test to the local MI result.
- usesAperiodic-corrected sigma power did not separate SOZ from normal SEEG pairs in 40 patients
The original byte-range EDF pipeline and the per-patient AUC and sign-flip statistics design come from this package.
- usesIn 43 SEEG patients, sleep HFA did not decline with contact-step distance from the clinical SOZ
Per-pair HFA and MI features for the 30-120 s window (results/pairs.tsv) and the upstream byte-range provenance.