Excitatory input had a larger mean 50 Hz response change in one Allen mouse sample, with an uncertain result after distance matching

We compared excitatory and inhibitory input response changes at shared target neurons in Allen Synaptic Physiology r2.1 mouse visual-cortex slices. The main sample had 29 targets, 65 connections, and 28 inferred mice. The equal-donor mean excitatory minus inhibitory late-train change at 50 Hz was 0.345 reference-amplitude units, with a 95% donor bootstrap interval of 0.214 to 0.478. A strict soma-distance match kept ten mice and gave 0.050, with an interval of -0.122 to 0.246. Source-class agreement and separate target-class checks preserved the positive ordering, but the distance subset limits a general rule. Human data had only three targets from two donors. Recovery checks were uncertain. This is a comparison of normalized responses from separately stimulated inputs, not an excitation to inhibition conductance ratio or a causal wiring effect. Small selected slice graphs, inferred donor labels, source mixtures, normalization, and fit error limit inference. The package provides code, data provenance, derived evidence, figures, and independent checks.

Allen Institute · synaptic dynamics · convergent inputs · excitation and inhibition · short-term plasticity · shared target · distance matching