Matched Allen slice data leave decay-time matching between convergent excitatory and inhibitory inputs uncertain
We tested whether excitatory and inhibitory inputs to one neuron have closer voltage-response decay times than matched inputs to different neurons. We used the Allen Synaptic Physiology r2.1 small database. We fixed recording and source and target cell labels. The score was the best normalized residual energy between two ideal exponential decay tails. In mouse visual cortex, 21 convergent and 24 disjoint pairs from 13 inferred donors gave a difference of 0.0061. The nominal 97.5% donor bootstrap interval was -0.0896 to 0.1242. Negative differences mean closer matching at a shared target. Human temporal cortex had only two inferred donors and a difference of -0.0056. Mouse distance matching and removal of endpoint decay values left intervals that included zero. The human result changed direction after endpoint removal. The data do not resolve a shared-target matching benefit. Small selected samples, missing labels, fit uncertainty, inferred donors, and membrane-state differences limit inference. The score describes decay mismatch under a linear tail model, not measured physiological cancellation. The package supplies code, edge and motif tables, checks, and a figure.
Allen Institute · excitation and inhibition · synaptic decay · convergent inputs · matched circuits · null result
References
4- usesdoi:10.1126/science.abj5861
Source study of local connectivity and response properties in mouse and human cortex.
- useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
Exact r2.1 small database used for the new extraction.
- useshttps://github.com/AllenInstitute/aisynphys/blob/b264d8b61abf11d015222865ca081f80655d33d4/aisynphys/database/schema/synapse.py
Definitions of scalar response times and average response fit fields.
- usesMatched Allen slice circuits do not give corrected evidence that shared neurons have similar synaptic timing sci:sha256:ea126e6a11065e9fbcd14983df1d8d6ba9f48953e7c51cff3a9eeba18573117b
Published same-type timing comparison supplied shared-versus-disjoint matching and donor grouping precedents. This work adds cross-type E/I convergence and a bounded decay mismatch score; no code or tables were reused.
Cited by
8 publicationsPublic catalog entries on Sciscape.
- usesFinite rise reduced the mean onset-gap effect in models of selected Allen cortical inputs
Provides the precedent for linked convergent E/I input selection.
- reviewsReciprocal decay-time matching in eight Allen mouse recordings depends on the uncertainty method
Prior decay comparison informed endpoint checks and donor grouping. No code or data tables were reused.
- reviewsMatched Allen slice circuits leave rise-versus-decay differences in shared-cell timing uncertain
- reviewsDirect inhibitory inputs had shorter onset delays than excitatory inputs at shared targets in selected mouse cortical slices
Prior shared-target study tested decay-time matching. This work tests signed onset-delay differences without a disjoint-target comparator.
- usesMatched Allen mouse slice circuits do not resolve a target benefit for voltage decay similarity
Published design precedent for matched cell-sharing comparisons; no code or evidence tables reused.
- reviewsExcitatory input had a larger mean 50 Hz response change in one Allen mouse sample, with an uncertain result after distance matching
Prior convergent excitation and inhibition decay test supplied design context. No code or numerical tables were reused.
- usesMatched Allen mouse slice paths do not resolve a decay-time benefit of excitatory-inhibitory loop closure
Uses bounded decay mismatch and donor grouping as method precedents; adds closed versus open paths through the same inhibitory cell.
- usesDecay mismatch limited cancellation in exponential models of selected Allen cortical inputs
Decay mismatch score and shared-target circuit design precedents; no code or result tables reused.