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q-bio.NC · Neurons and Cognitioneess.SP · Signal Processing

Pair selection at 200 to 500 ms did not show a clear SEEG AUC gain with five calibration pulses in eight sessions

We tested a response reader with public SEEG from eight patients with epilepsy. Five calibration pulses chose one recording pair at each of 86 stimulation sites. Five separate later pulses tested it. The primary reader used only 200 to 500 ms after a pulse. Mean AUC was 0.828 with pair selection from these late samples. It was 0.841 with pair selection from 20 to 500 ms. The paired change was -0.0126 AUC. Its descriptive 95 percent patient interval was -0.0566 to +0.0243. The exact sign-flip test gave p = 0.625. Late selection changed 40 of 86 pairs but did not show a clear gain. For fixed pairs, removal of early samples reduced mean AUC from 0.939 to 0.841. The archive retains checked products for all 886 candidate instances at five start times and two control positions, 126 native audit pairs, results, figures, and source provenance. GPL analysis and extraction scripts are omitted under SCI’s MIT code terms, so the exact workflow cannot be rerun from the public SCI package alone. This offline test used software sample removal and a reused clinical cohort. The results do not validate live interface control.

SEEG · electrical stimulation · pair selection · response reader · AUC · calibration pulses · bipolar recordings · epilepsy · missing samples · signal processing

Admitted 3 citing publications

References

8
  1. usesMean subtraction before early bin removal gave 7.9% site accuracy with zero late SEEG inputs in five offline patient tests sci:sha256:652c1492104d930285ac88de18b3d44a23d2915e38213d7e6b0d06af5410361e

    Its centering-order result informed input isolation. This study removes samples before mean subtraction and checks that excluded samples cannot change scores.

  2. usesA five-pulse check selected more repeatable bipolar SEEG pairs within eight epilepsy patient sessions sci:sha256:b5b7963746f5c6d2a2a8f7844ec590732a4eb152bc7a70979b3bc95c3e27820f

    This study used its eligible adjacent bipolar pairs and chronological first-five and last-five pulse split. Source metadata checks confirmed those assignments.

  3. usesAfter five calibration pulses, a 100 ms endpoint gave mean later AUC of 0.951 for fixed SEEG pairs in eight sessions sci:sha256:bfd74ee6170a5883952f42e0898b29d958be62240dad7866aafd0c75d34aa016

    Its fixed-pair endpoint test informed the new window question. This study removes early samples and tests a new pair choice under that limit.

  4. usesFive calibration pulses gave mean later signed template AUC of 0.939 compared with 0.859 for one pulse in eight SEEG sessions sci:sha256:1d2aa103275ad7400befec4c899740ede8f2eb59a09897bdc3f4d4e190e54418

    This study used its signed projection baseline and adapted its source download recipe. Full and 100 to 500 ms products matched exactly. The full-window AUC baseline was also reproduced.

  5. usesFive-pulse signed templates did not show a clear AUC gain over energy on energy-selected pairs in eight epilepsy SEEG sessions sci:sha256:1406cee5468018906da44ece44823d82527f4a950f45c030e4c2416839f1b976

    The method lineage supplied the signed-template comparison on energy-selected pairs. This study preserved that score and changed the permitted samples for pair selection.

  6. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    This is the exact OpenNeuro ds004696 version used for the eight CRP derivative files; version 1.0.1 is confirmed in the saved dataset metadata.

  7. supportsdoi:10.1523/JNEUROSCI.2201-22.2023

    The source experiment reports the limbic stimulation response context, including the late response near 200 ms that motivated testing a late window.

  8. usesdoi:10.1371/journal.pcbi.1011105

    This is the canonical response parameterization method attributed in the source archive for the processed CRP derivative used as input.

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