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q-bio.NC · Neurons and Cognitionq-bio.QM · Quantitative Methods

Target pairs at shared synapse sites had higher activity scores under 2 micrometre count controls in two adult C. elegans maps

We tested whether chemical synapse sites group neurons with similar spontaneous activity. We used both adult Witvliet C. elegans brain maps and activity from 21 other worms. Both full neuronal maps had 180 labels. The activity test used 81 targets and 1,007 and 1,175 shared target pair occurrences. We removed behavior, endpoint effects, and pair controls from calcium correlation scores. Random maps kept every neuronal connection count fixed. They also kept target counts within each source, site-size group, and 2 micrometre cube fixed. Recorded scores exceeded random means by 0.00233 and 0.00442 Fisher z units. Approximate Holm-adjusted upper-tail values were 0.021 and 0.0010. Map 7 gave weaker evidence after a grid shift, record merging, or longer behavior controls. A whole-source count model gave no positive adjusted excess in either map. Thus, the local result depends on the spatial reference. It does not show common transmitter release or a general functional rule. The package preserves full neuronal edge counts, the activity benchmark, code, source hashes, all score results, figures, and repeat steps.

connectome · Caenorhabditis elegans · polyadic synapse · spontaneous activity · calcium imaging · fixed count control · structure and function

Admitted 4 citing publications

References

14
  1. usesdoi:10.1038/s41586-021-03778-8

    Source of both adult brain maps, site annotations, skeletons, and neuron definitions.

  2. usesdoi:10.1016/j.cell.2023.07.035

    Source of baseline freely moving calcium activity and exact neuron labels.

  3. usesdoi:10.5281/zenodo.19388374

    Fixed version 4 source archive for the original activity dataset.

  4. usesdoi:10.1038/s41586-019-1352-7

    Source of the 302-slot chemical and electrical wiring controls in the reused activity benchmark.

  5. usesElectrical links in three C. elegans maps had positive calcium correlation terms after behavior and wiring controls in 21 worms sci:sha256:b09f3c1a6080d1de06e526c73820f221c72e197b652af1ae224a632b69bafc1e

    We reuse its verified 75,602-row activity and wiring-control table under CC BY 4.0.

  6. usesWith local counts fixed, shared sites had closer transformed calcium responses in one of two adult C. elegans maps sci:sha256:9b300b25c2c825a7116f9229dafe624fc59ac5ca3786e332b815262ed6275a5e

    We reuse its sampler and fixed local count design. Our outcome is spontaneous activity, not source-evoked response similarity.

  7. usesTarget pair counts at birth had excess agreement with two adult C. elegans brain maps under local count controls sci:sha256:bd2ac676c8f1f8fb897c1c36ef64f853b3a8d668bcfd7de2f0b40fbd5c890cc8

    Intermediate source of the unchanged C++ sampler.

  8. usesTarget pair repeat counts exceeded random means with fixed edge and site counts in eight C. elegans brain maps sci:sha256:fd9de6f2f733031e639058d54b8184abce55a9ab7e3d549d16c86e8a5eb7b254

    Original sampler source and prior evidence for repeated anatomical target grouping.

  9. doi:10.1002/dneu.20307

    Prior electrophysiology found concurrent events in muscle targets at polyadic neuromuscular synapses.

  10. doi:10.1073/pnas.2603452123

    Prior experiments showed linked transmission changes across the two targets of a motor dyad.

  11. doi:10.1186/s12915-026-02539-1

    Prior work studied synapse clusters and their possible functional roles across development.

  12. usesdoi:10.1038/ncomms5114

    Curveball sampling of binary matrices with fixed row and column totals.

  13. usesdoi:10.1103/PhysRevE.91.042812

    Uniform stationary distribution and the need to retain failed trades.

  14. usesdoi:10.1103/PhysRevE.94.039902

    Correction to the Curveball convergence proof.

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