The mean response minus pre-pulse SEEG order score was 0.001 at 15 fixed readouts in five sessions at 20 to 500 ms

We compared nearby and far pulse waveform differences in public OpenNeuro ds004457 version 1.0.2. The sample had five clinical patient sessions, 138 stimulation sites, 15 fixed bipolar readouts, and 1,436 eligible 6 mA pulse records. Nearby pairs had index lag one. Far pairs had lag at least half of each site's pulse count, rounded up. At each readout, the score was far minus nearby mean squared distance, divided by all-pair mean distance. The primary mean response minus pre-pulse score at 20 to 500 ms was 0.001 (-0.022 to 0.034). Parentheses give a descriptive 95 percent whole-patient bootstrap interval. The interval included zero. The planned 20 to 100 ms check gave 0.083 (0.024 to 0.140); four patients had positive contrasts. A late-window check gave -0.028 (-0.064 to -0.003). These secondary results have no adjusted inference. The run freshly verified 110 source files and rebuilt all 2,453,000 archived voltage bins exactly. Three figures, code, all pulse maps and distances, a local plan, and source retrieval instructions are preserved. The score cannot prove pulse independence or a useful stimulation schedule. This is an extension of prior order audits, not an independent cohort test.

SEEG · electrical stimulation · pulse order · waveform distance · brain-computer interface

Admitted 2026-11-09 20:03 UTC5 citing publications

References

usesA joint SEEG shape decoder did not show a clear mean gain over one selected pair in four patient sessions sci:sha256:81f77d4f52365d5b14fed7d3d6db7b430a2cf478b9a6a6062540c4e90bbd8e7c
The inherited MIT retrieval and MEF extraction code originated in this package. Its source unit conversion, integer bin boundaries, and metadata retrieval support the fresh raw-data rebuild. Attribution is retained.
usesFirst and final four-pulse SEEG means had a mean ratio of 1.071 against balanced splits in five sessions at 20 to 500 ms sci:sha256:402c112918b898886585ea4478d5e20055479fdaa17e9846c662958ed6e02d14
This prior audit tested first and final groups of four pulses in the same five sessions. Its result and off-shaft scope informed the present extension to all eligible pulses and a far-index-lag score. The current result is not new independent patient evidence.
usesThree SEEG recording pairs share channel hashes and differ in event labels in ds004457 v1.0.2 and ds004696 v1.0.1 sci:sha256:9f29610431edacf4fe7a6597dfc16e60f353657563c522ba96e16fcda1cb6c9b
This audit found three shared recordings in ds004457 and ds004696. That evidence prevents an independent-cohort interpretation of agreement with the ds004696 pulse-order audit. The report states this limit.
usesAt ranks set by 80% pre-pulse fit energy, pre-pulse PCA retained less repeated site voltage than response PCA in five SEEG sessions at 20–500 ms sci:sha256:2cd29c089f1d0466b782df1321baedf3de9e9cf870ccf7dc5daa86273e8d6ef6
This package supplies the complete selected-contact 5 ms voltage bins, fixed contact targets, source manifest, and MIT retrieval and extraction code. The new analysis keeps all eligible off-shaft pulses and compares far and neighboring waveform distances with equal-duration pre-pulse controls.
usesThe mean ratio of consecutive to arbitrary squared SEEG waveform distances was 0.992 at 20–500 ms in eight patients sci:sha256:7772d57bfdee850ed680e7353c67d8ecc95969cd51d402613157a1df8cf0e9fb
This prior audit compared consecutive and arbitrary waveform distances and explained the exact uniform-order reference and its independence limit. The new endpoint compares far and neighboring distances and subtracts a reflected pre-pulse score. Prior early-window results informed the fixed window checks.
usesdoi:10.18112/openneuro.ds004457.v1.0.2
The analysis used raw recordings and metadata from ds004457 version 1.0.2, checked 110 selected source files against preserved hashes, and rebuilt the archived voltage bins.
usesdoi:10.1523/JNEUROSCI.1325-22.2023
This is the source study for the OpenNeuro recordings analyzed here.

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usesStudent t scores reduced mean probability loss with simulated fourfold voltage gain in five SEEG tests at 100–500 ms
Uses its hash-preserved voltage bins, fixed recording pairs, remote-site cohort, and retrieval and extraction code. A fresh raw rebuild verifies the shared inputs.
usesAn early SEEG gate had a 2.44-point mean utility gain with a 95% interval across zero at a 0.05 delay cost in five sessions
This package supplied the fixed remote-shaft cohort, 5 ms voltage bins, events, source metadata, pinned source manifest, and extraction code. Fresh source extraction reproduced its voltage arrays exactly.
usesMinimum split selection gave 40.0% mean SEEG accuracy at 100–500 ms for eight sites in five offline sessions with four calibration pulses per site
We used its compact voltage bins, source metadata, extraction code, and fixed contact rules. These inputs defined the 138 candidate sites in five sessions.
usesA fixed SEEG reader showed excess contact overlap in wrong site calls at 20 to 100 ms in five patients
This publication supplied the exact compact SEEG data, source metadata, remote-shaft cohort, pulse order, and hash-pinned raw rebuild code. The new study tests spatial error structure.
usesFinal five pulses showed no clear 20–100 ms SEEG order contrast at fixed readouts across 314 sites in eight people
We use its normalized far-minus-near distance score and its early-window result to motivate this fixed five-pulse extension. The recordings partly overlap. The present protocol changes pulse groups, readouts, processing route, and cohort size. It does not isolate which change explains the different estimate.