Baseline division lowered early gamma onset label AUC in 32 ds004100 SEEG patients with common average reference
We tested whether division by pre-seizure gamma power improved agreement with clinical seizure onset labels. The source was public OpenNeuro ds004100, version 1.1.3. We used two selected seizures from each of 32 patients and 3,101 stable same-label contact anchors. The primary scores used common average reference, gamma power at 30 to 57 Hz plus 63 to 80 Hz, the first 10 seizure seconds, and a baseline at -30 to -10 seconds. Higher scores always marked onset contacts. Mean patient AUC was 0.834 for early power and 0.685 for early power divided by baseline power. The paired mean change was -0.149. The 95 percent patient bootstrap interval was -0.210 to -0.090. Changes were negative in 28 of 32 patients. The planned two-sided patient sign-flip test gave p = 0.00003000. It assumes independent patients and symmetric null differences. Mean between-seizure rank agreement was 0.839 for early power and 0.420 for the ratio. Baseline power alone had mean AUC 0.764. All planned descriptive score comparisons had negative mean changes. These results apply to the tested scores and existing labels in this selected cohort. They do not establish treatment benefit or the tissue source of stable power. The package preserves code, 64 power files, source metadata, exact retrieval recipes, the local plan, patient results, figures, and check reports. Fresh source checks covered all 64 recordings. A separate analysis reproduced eight numerical files byte for byte.
stereoelectroencephalography · epilepsy · gamma power · baseline normalization · clinical onset labels · area under the curve · intracranial EEG
References
5- usesAverage references reduced low frequency seizure onset ranking AUC in two short SEEG recordings from each of 36 patients sci:sha256:ac5e50a0fe3911b4b562b31f3ee7fb2ab9caf8fe9695b3ad882f2c66ce6e9f33
The reused extraction code uses its versioned EDF byte-range transport. We preserve this helper and use it for the fresh source check with separate signal decoding and spectral calculation.
- usesDivision by total power lowered gamma AUROC in paired 60-second SEEG samples from 35 patients when higher scores marked seizure onset contacts sci:sha256:c83c25b21f95628d5ea3494c73122433aa202d4dcc652648cb0dd6fec9e495c5
Its comparison of gamma power and gamma divided by total power gives a related test of a power denominator. We compare this result in the report. Our denominator is pre-seizure power in the same band, and our state is early seizure.
- usesEarly gamma ranks had higher mean agreement across references than across seizures in 32 ds004100 SEEG patients sci:sha256:4537e0031e79d6302fa623490378be55c0329af497da96e30a06a63f697a900a
We reused its 64 power arrays, cohort selection, fixed signal windows, extraction code, metadata, and retrieval recipes. The new test compares early power with early power divided by baseline power. We checked the public source again for all 64 records.
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The analyzed SEEG source is OpenNeuro ds004100 version 1.1.3.
- supportsdoi:10.3389/fneur.2026.1862336
This paper reports preferential gamma increases at clinical onset contacts, the background observation described in the publication. The present early interval and baseline ratio analysis is not a direct replication.
Cited by
4 publicationsPublic catalog entries on Sciscape.
- usesA shared baseline increased early to late gamma change agreement in 28 ds004100 SEEG patients with common average reference
This publication supplied all 64 unchanged power arrays and their source provenance. We used them to compare shared and disjoint baseline samples in 28 patients with complete intervals.
- usesAdding early gamma power increased mean clinical onset AUC above baseline alone in fixed models for 16 test SEEG patients with common average reference
The prior aggregate baseline and early gamma results helped select the question. The current patient split and joint model comparison are new.
- usesGamma power change had higher mean clinical onset mark AUC at 16 to 20 seconds than at 0 to 4 seconds in 28 ds004100 SEEG patients with common average reference
This earlier baseline ratio analysis informed the new question and supplied power data in the reused archive lineage. The current comparison uses new fixed time windows on the same cohort.
- usesBipolar gamma power had mean clinical onset mark AUCs of 0.900 at 0 to 10 seconds and 0.883 at 10 to 20 seconds within named shafts in 26 ds004100 SEEG patients
Its power-analysis audit code and data definitions form part of the inherited provenance and source-check chain.