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Fixed tests did not confirm shared load or phase changes in response spread in 12 SEEG patients and two fMRI samples

We tested whether memory load and task phase change trial response spread in separate human SEEG and fMRI studies. Development used three people per modality for load. A fixed test used 12 other SEEG patients and 16 other fMRI adults. High-minus-low mean scaled variance was -0.08509 in SEEG (95% person t interval -0.17131 to +0.00114) and -0.01395 in fMRI (-0.18128 to +0.15337). The shared decrease test failed. A separate phase follow-up used new equal-duration SEEG indices and a reserved second fMRI experiment. Confirmation used the 12 patients and 11 fMRI people absent from the first experiment. Delay-minus-encoding mean variance was +0.09450 in SEEG (-0.05190 to +0.24090) and +0.02977 in fMRI (-0.08940 to +0.14894). Both phase directions failed. All four shared directions had publication-wide Holm p=1 and failed the signed-interval rule. Negative and discordant checks remain. These failures do not establish equal spread or a shared neural mechanism. The package adds 1.16 MB of new phase indices for 15 patients from 1.78 GB of hash-checked raw data, fixed-source MRI extraction, all person scores, plans, code and repeat instructions. A second arithmetic route checked all 51 primary scores. A full raw rebuild matched all 15 new SEEG files, and a numerical replay matched eight result files exactly. Clinical sampling, different tasks and cohorts, spectral precision, source region selection and beta-error covariance limit interpretation. Exact BOLD trial rows and raw EDF files remain external under their source terms.

working memory · SEEG · fMRI · trial variability · response spread · negative results · reproducible data · human neuroscience

Admitted 6 citing publications

References

11
  1. usesA second fitted load pattern raised mean test error in 12 SEEG patients and 16 fMRI adults sci:sha256:957819a5e22f1f7f704edf4006247457f5c7fe5bcc06b9099d1bf430d2a9ddf2

    We reuse its compact SEEG maintenance features, source provenance, and unchanged fMRI fetcher and table parser.

  2. usesUnder patient independence and sign symmetry, testing did not detect a late theta spread difference between four and eight letters in 12 SEEG patients sci:sha256:0c914544191c3a520f29d1c3699729cd84ea376ea81fb73f4fc655aacdc9928a

    Its uncertain late theta spread test informed scope and confound checks before confirmation. Our broader feature and MRI tests are distinct.

  3. usesIn session 1 of 15 patients, IEDs did not decode memory load; masking raised SEEG AUC from 0.70 to 0.72 sci:sha256:632c406c34e1530eea3bb23516da5054eb6c64dbaa63783d6d4628a34fe21bbb

    Its archived feature extraction and source notices are retained through the verified SCI 93b4e0e6 package. The new phase extraction starts from raw source data.

  4. usesdoi:10.18112/openneuro.ds004752.v1.0.1

    Fixed source for all original SEEG trials and the new equal-window phase derivative.

  5. usesdoi:10.7554/eLife.78677

    Source SEEG study and required dataset attribution.

  6. usesdoi:10.18112/openneuro.ds001634.v1.0.1

    Original Study 1 fMRI dataset; the analyzed author derivative is pinned separately.

  7. usesdoi:10.18112/openneuro.ds001635.v1.0.1

    Original Study 2 fMRI dataset; we test new people using the pinned author derivative.

  8. usesdoi:10.1038/s41467-019-08840-8

    Source of both fMRI experiments and their released beta tables and region definitions.

  9. doi:10.1016/j.neuron.2025.10.015

    Prior human work on task-dependent neural variability motivated the phase question; our measurement summaries and scope differ.

  10. doi:10.1016/j.neuropsychologia.2022.108280

    Prior study of BOLD variability and working memory load.

  11. doi:10.1126/sciadv.aav3687

    Prior human work on population activity during verbal memory maintenance.

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