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A fixed test did not confirm a response level and repeat spread relation in human SEEG and two fMRI groups

We tested whether larger measured responses mark greater repeat spread within fixed nonvocal sound panels. Separate public human studies supplied SEEG high-gamma activity and two fMRI cohorts. Different repeats supplied response level and squared response difference. Disjoint sounds supplied site scales. Development used two patients and four MRI adults. Fixed tests used six other patients, sixteen other B2021 adults and eight NH2015 adults. Mean dimensionless covariances were 0.090441, 0.019761 and 0.016203. Pointwise 95% person t intervals were [0.039348,0.141535], [0.010382,0.029139] and [-0.008269,0.040675]. The declared three-cohort rule failed, conjunction p=0.080705. Global repeat-gain alignment retained a positive SEEG interval but left both fMRI intervals across zero. A ten-site fMRI check was discordant. An exact gain-only model gave a positive score with no additive noise. An added estimator check showed why skew can bias a same-repeat mean-variance covariance; human differences were not uniform across studies. All negative outcomes remain. An independent sound-pair calculation checked all 36 development and test people within 5.56e-17. Source selection, shared normalization, separate cohorts, finite repeats and measurement filters limit neural interpretation. The contribution is an audited assay, narrow raw measurement evidence, and a failed broad confirmation test. The package preserves code, source terms and hashes, plans, all results, figures and repeat instructions. Original neural arrays remain external. No shared neural noise law or cause is established.

human neuroscience · SEEG · fMRI · auditory cortex · measurement variability · repeat gain · sample skew · reproducibility

Admitted 6 citing publications

References

9
  1. usesTwo fixed voice volume tests did not confirm shared effects in six SEEG patients and 24 fMRI adults sci:sha256:9b3d595e0b8e51f670afe0ac3c4b1cb85fdb9298e50d70e3ab00725ef36ae11b

    We use its exact source pins, category rule and repeated-response extraction procedure. The covariance endpoint is new.

  2. A smooth acoustic kernel did not pass a shared gain test in 14 iEEG patients and 8 fMRI adults sci:sha256:a74e86c25b5837e13b02d6d737255a5955fcd70f1cdccadf9807aedf5953f14a

    Related auditory model benchmark read during question selection; its electrical data are not used.

  3. doi:10.1523/JNEUROSCI.0156-16.2016

    Prior human auditory high-gamma mean-variance analysis.

  4. usesdoi:10.1371/journal.pbio.3001675

    Source SEEG experiment.

  5. usesdoi:10.5281/zenodo.6544488

    Version-specific data and code release, v1.1; GitHub bytes are pinned by commit and hashes.

  6. usesdoi:10.1016/j.neuron.2015.11.035

    Source NH2015 fMRI experiment.

  7. usesdoi:10.1152/jn.00588.2020

    Source B2021 fMRI experiment.

  8. usesdoi:10.1371/journal.pbio.3002366

    Author fMRI response and anatomical metadata archive; exact container and member hashes are preserved.

  9. doi:10.1198/000313007X188379

    Standard result for covariance of sample mean and sample variance; the package includes its own derivation and exact check.

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