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An early timing check selected SEEG pairs with higher mean 10 ms peak precision in a 20–500 ms window in eight patient sessions

We tested 886 remote bipolar SEEG readout pairs at 86 stimulation sites in eight patients with epilepsy. We used public OpenNeuro ds004696 version 1.0.1 voltage traces. A shape check used the first two and next three pulses. An added timing check required their largest absolute peaks to differ by at most 10 ms. We scored the first-five and final-five mean peaks in a 20–500 ms window. The added check selected 140 pairs, compared with 196 for the shape check. The equal patient mean timing precision was 88.4% and 77.0%. The mean difference was +11.5 percentage points. Its descriptive patient bootstrap interval was +4.4 to +18.0 points. Of 183 selected pairs with later shape correlation at least 0.8, 40 failed the timing target. These within-session results do not test an online BCI. The package preserves exact means, all scores, source hashes, four figures, and code. A finite-grid proof and a counterexample show why shape correlation alone cannot bound peak time.

SEEG · dominant peak · peak timing · waveform shape · brain-computer interface · electrical stimulation · repeatability · epilepsy

Admitted 7 citing publications

References

4
  1. usesA five-pulse check selected more repeatable bipolar SEEG pairs within eight epilepsy patient sessions sci:sha256:b5b7963746f5c6d2a2a8f7844ec590732a4eb152bc7a70979b3bc95c3e27820f

    We used its eight-patient bipolar cohort, source manifest, pulse rules, and processing audit. We reloaded all source voltage files and checked its shape scores before measuring dominant-peak timing.

  2. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    This exact OpenNeuro version supplied the eight processed voltage files used in the analysis.

  3. doi:10.1523/JNEUROSCI.2201-22.2023
  4. doi:10.1371/journal.pcbi.1011105

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