Peptide pair counts raised ridge test error by 0.20% for WT and unc-31 response differences in 1,342 C. elegans atlas pairs
We tested whether a published peptide map adds prediction value for response magnitude differences between wild type and unc-31. We used 1,342 matched C. elegans atlas pairs with at least three finite trials per strain. Four anatomy exports retained every recorded neuronal edge. The molecular map had 302 neuron labels and 92 gene pairs. Five folds kept reverse directions and repeated expression profiles together. A ridge model used wiring, cell identity, trial counts, distance, and expression breadth. Adding the known pair count raised test mean squared error from 0.256491 to 0.256998, an increase of 0.20%. Its conditional error reduction range was -1.12% to +0.40%. The count score was ordinary among 999 specificity-label changes, with conditional rank p=0.541. A later model with 92 separate channel weights and nested penalty selection gave an error reduction of -0.018%. Its rank among 200 broader fixed-margin controls was 0.493. Equal trial counts left a mean count gain of -0.189% in 20 draws. These results extend a prior binary-detection test. They give no evidence of added value under the tested quantitative models. They do not show that peptide signaling has no effect. Sparse mutant trials, different strain protocols, and data from different animals limit biological inference. The package preserves input facts, source hashes, code, fitted states, predictions, molecular controls, figures, and repeat instructions. A clean replay reproduced 22 numerical files exactly.
connectome · neuropeptide · signal propagation · C. elegans · unc-31 · molecular specificity · quantitative response · prediction benchmark
References
14- usesA peptide match count gave no stable prediction gain in fixed tests of 1,278 C. elegans response directions sci:sha256:3018776ea40d60cb03a98946ae55b67eeafde1153c906d69ac22d5b59fab6cd1
We extend its peptide count detection question to continuous response magnitude differences and channel-specific models in the same atlas.
- usesTerms for wiring direction raised Brier error in fixed WT and unc-31 models of 3,261 C. elegans atlas pairs sci:sha256:ee400d9bbdac90339b80dc2aa2c5f80acbe6aab928af804f74d149eb15909a65
We reuse and independently audit its matched assay facts, complete native neuronal edges, and node panel.
- usesPredicted self-signaling pair counts fell within matched receptor profile ranges in 127 C. elegans expression groups sci:sha256:70c513a1b25c8f973e923136e6aae7e5ea6deff017b8baaf05011f76e608ea52
We reuse binary gene expression, known gene pairs, and continuous expression-profile groups.
- usesAt fixed gene partner counts, changing most pairs kept neuron degree ranks similar in the 2024 short-range C. elegans peptide map sci:sha256:ad48c7fa79305861e670b50997a255aa8e7fe74149ae6dcebbeb3acfae360218
We reuse 200 fixed-margin molecular graphs to test added prediction value for measured function.
- usesAnatomy reduced ridge test error by 4.35% in wild type and increased it by 0.98% in unc-31 for 1,342 matched C. elegans atlas pairs sci:sha256:94b719902ca9f7ce3566f097497f5496034370c4e3341b81a5ffb5a82bbb6396
Its matched quantitative anatomy test guided the response transform, ridge baseline and trial count checks.
- usesdoi:10.1038/s41586-023-06683-4
Source neural activation response atlas and WT/unc-31 measurements.
- usesdoi:10.17605/OSF.IO/E2SYT
Source functional data collection.
- usesdoi:10.1016/j.neuron.2023.09.043
Source molecular peptide connectome and its network rules.
- usesdoi:10.6084/m9.figshare.c.6895870.v1
Versioned source peptide map data collection.
- usesdoi:10.1016/j.cell.2021.06.023
CeNGEN expression data underlying the peptide map.
- usesdoi:10.1016/j.celrep.2023.113058
Known peptide–receptor interactions underlying the molecular map.
- usesdoi:10.1098/rstb.1986.0056
Original anatomical source for White exports.
- usesdoi:10.1038/s41586-021-03778-8
Original anatomical source for two adult exports.
- doi:10.1371/journal.pbio.3003171
Prior evidence that chronic loss of UNC-31 can produce compensatory effects; it limits a simple causal interpretation.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- Chemical walk composition gave no stable gain in two ridge models of 1,342 C. elegans unc-31 responses
Prior quantitative test of peptide count features for strain response differences. We test chemical walk composition instead.
- Free positive cell gains fitted 1,342 C. elegans WT–unc-31 mean comparisons within 2.96 sample standard error bands
Prior quantitative peptide prediction test for the same response panel.
- usesPeptide channel terms gave an uncertain 1.93% timing error reduction in a nested ridge test of 739 C. elegans kernels
We reuse its numerical expression facts, whole-profile groups, and molecular channel names. This study changes the outcome from strain magnitude differences to fitted timing.