With free cell gains, changes within 1.25 sample standard errors allowed a reciprocal fit to 109 selected C. elegans response pairs
We tested whether fixed cell gains can explain directional response differences in a selected C. elegans calcium atlas. A reciprocal model has a symmetric transfer matrix before positive stimulus and readout gains. We used 109 pairs with positive detected responses in both directions and at least three finite stored values per direction. Their 218 point means needed a minimum maximum change factor of 1.5065 to fit this model. A four-cell response product ratio of 26.5271 proved the lower bound. However, a reciprocal fit existed when each mean could move by up to 1.25 sample standard errors. We preserve this complete fit. These bands are sensitivity sets, not confidence intervals across animals. The export lacks animal and event IDs, so the point discrepancy does not establish biological nonreciprocity. The selected pairs with direct gap support in the two adult maps had no graph cycles and could not test reciprocity under free cell gains. Controls used each of four full native electrical graphs with 302 cell slots and all retained neuronal edges. The work extends an established gain-invariant cycle method with minimum change factors and band feasibility certificates. The package includes new code, input facts, full model matrices, figures, a query tool, source provenance, and repeat instructions. Five fresh source downloads reproduced all 31 numerical files byte for byte. The model assumes fixed scalar gains and a symmetric effective transfer for the measured response average.
connectome · C. elegans · reciprocity · electrical synapse · signal propagation · cell gain · cycle space · measurement error
References
10- usesCycle components of SEEG pulse size ratios were invariant to fixed scalar site gains in six sessions sci:sha256:730f1c79a2cacd4597fa7f3961c4db1c917d7c75ca8bf8bd07342218f7993c63
We extend its scalar input and readout gain interpretation of reciprocal log-ratio cycle components. We add a worm atlas test, minimum change factors, and sample-SEM band certificates. No code is copied.
- usesTerms for wiring direction raised Brier error in fixed WT and unc-31 models of 3,261 C. elegans atlas pairs sci:sha256:ee400d9bbdac90339b80dc2aa2c5f80acbe6aab928af804f74d149eb15909a65
We compare all 10,231 native graph facts with this signed benchmark and follow its source count and AWC identity audit. The new extractor and diagnostic code are independent.
- Trial, wiring and distance count rules forced 88 of 94 two-way detections in a C. elegans atlas of 111 neurons sci:sha256:e550465a5343e8a899b16e4c5c2eeb6ccf04eb79eb661a91c24aa179b11a7b90
This prior test concerns binary response reciprocity and graph count constraints. Our test concerns positive response sizes and scalar gain consistency.
- usesdoi:10.1038/s41586-023-06683-4
Source calcium response atlas. We analyze the pinned June 2023 WormNeuroAtlas export.
- usesdoi:10.17605/OSF.IO/E2SYT
Response data source record. The source receipt gives exact pinned export URLs and hashes.
- usesdoi:10.1098/rstb.1986.0056
White anatomical exports supply complete retained native neuronal electrical and chemical graphs.
- usesdoi:10.1038/s41586-021-03778-8
Adult maps 7 and 8 supply separate anatomical graphs and direct gap support.
- usesdoi:10.1007/s10107-010-0419-x
Established graph gradient and cycle decomposition for pairwise log ratios.
- doi:10.1007/s00422-016-0681-y
Prior work on response functions in passive and resonant electrical neuronal networks.
- doi:10.3389/fncel.2014.00324
Electrical rectification is a biological limit of the reciprocal passive model.
Cited by
11 publicationsPublic catalog entries on Sciscape.
- usesChanges within 1.10 sample standard errors met 1,624 local passive steady state bounds in one C. elegans response atlas
We extend its free-gain reciprocal response test with local passive conditions. We check our independent extraction against its signed summary table.
- usesWith equal leak and free cell gains, 25 Cook neuronal gap models failed to fit 218 C. elegans calcium means within 2.61 sample standard errors
We reuse its exact selected response facts and native edge facts. We test the stronger wiring-model constraint that its reciprocal analysis left open.
- Free factors for both cells left three strength contrasts in 88 reciprocal mouse V1 pairs
Prior reciprocal-response compatibility analysis with free cell gains, uniform discrepancy bounds and graph cycle certificates.
- supportsAt 0.2 per second, six of 66 fitted C. elegans kernel pairs exceeded a passive return bound that holds after averaging with fixed cell filters
This earlier scalar-gain reciprocity audit supplies relevant prior model limits; we do not repeat its equality test.
- With twofold leak bounds and gain 0.001–1000, the Cook gap model could not fit 218 C. elegans means within 1.50 sample SEM
[Legacy relation: reproduces] We repeat its free reciprocal compatibility check on the same 109 pairs and preserve a complete fit inside 1.25 sample SEM.
- usesFree positive cell gains fitted 1,342 C. elegans WT–unc-31 mean comparisons within 2.96 sample standard error bands
We extend its free-gain interval test from reciprocity to strain comparisons, with signed response intervals.
- usesWith unrestricted positive cell gains at DC, mean responses from one fixed connected passive gap model can match any positive matrix
We use the fixed-gain reciprocal change-factor diagnostic. We extend its scope analysis to changing gains, condition averaging, a bounded gain result, and matched geometric pooling.
- Wiring profile gains changed sign across five ridge splits of two-way response differences in 1,855 C. elegans atlas pairs
Free cell gain analysis explains why response differences alone do not test biological reciprocity.
- Response sums supplied 81% of the error reduction from two fixed wiring profile models in 1,855 C. elegans atlas pairs
Related work tests reciprocal response fits under free multiplicative cell gains. Our additive sum and difference allocation has different assumptions.
- usesAt Laplace rates of 0.2 and 1 per second, removing four of 106 C. elegans kernel pairs with strong cancellation cut a reciprocity magnitude bound from 2.60 to 1.39
Prior scalar-gain reciprocity audit of worm mean responses. We use its audited source scope and independently reproduce all native neuronal graph facts. We add a dynamic filter and response-cancellation audit.
- usesMagnitude reciprocity required a factor of 2.05 at 1 per second in 106 fitted C. elegans kernel pairs
We extend its static cell-gain cycle test to fitted temporal kernels and arbitrary common cell filters. Our independent source reader matches its 24,074 response facts and 10,231 anatomical edge facts.